Abstract: We tested the activity of anticancerous compound tamoxifen (TAM) using the standard CLSI guidelines against filamentous fungi including Aspergillus spp, P. marneffei, Mucor and Rhizopus in a microplate based assay. MIC/MEC endpoint was calculated against drugs fluconazole, itraconazole, caspofungin (commercially known as Cancidas) and TAM. The endpoint of TAM was found to be 16-64µg/ml after 24-48 hrs with reduced filamentation at sub MIC concentrations. Our results imply that TAM affects the growth of various filamentous fungi tested, including Aspergillus (sp.), Penicillium, Mucor and Rhizopus. To our knowledge, this is the first report of TAM with antifungal activity against filamentous fungi.
Keywords: fungi, filamentous, yeast, drug resistance, Aspergillus.
Title: First report of Antifungal activity of Tamoxifen against Filamentous Fungi
Author: Ritu Pasrija, Deepika Kundu
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Research Publish Journals
