Abstract: The idea of delivering drugs through skin is old, as the use is reported back in 16th century B.C. A skin patch uses a special membrane to control the rate at which the liquid drug contained in the reservoir within the patch can pass through the skin and into the bloodstream. Many drugs that not having desired parameters for penetration their penetration enhanced with incorporation of the penetration enhancers. Metoclopramide hydrochloride which, is used as dopamine receptor antagonist antiemetic. short half-life ,low dose and low melting point, and their respective properties makes Metoclopramide hydrochloride good candidate for the Transdermal drug delivery. The laminated transdermal films of MCP prepared with different grades and ratios of Eudragit RS-100, EugragitRL-100, HPMC-E5 and EC holds potential for transdermal delivery of Metoclopramide hydrochloride and evaluation study has been done. A 32 factorial design was applied to prepare transdermal film of Ethyl cellulose Eudragit RL100, Eudragit RS-100 polymer as membrane and incorporation of drug in hydroxyl propyl methyl cellulose film as a matrix and to study its effect on evaluation parameters. In order to understand mechanism of drug release, in vitro permeation data were treated to kinetic models and linearity was observed. The correlation coefficient obtained from Korsemeyer Peppas as best fit model, r value was found to be 0.9903(F7), 0.9885(F8) and 0.9948 (F9). The optimized patch F9 the required patch size calculated, 25.10 cm2 patch is required to get desired concentration of drug.
According to Design Expert Software formulation F9 was the best formulation having cumulative amount of drug permeated 3.79 mg/cm2, 99.43 drug content 109.75 Tensile strength and moisture content and moisture uptake 2.24 and 2.47 respectively.
From the formulation F9 formulation is the best formulation with desirability factor 0.678 and drug release is 66.97%
Keywords: metoclopramide hydrochloride, transdermal patch, permeation enhancer, eudragit RL100, hydroxy propyl methyl cellulose.
Title: Formulation and evaluation of metoclopramide hydrochloride transdermal patch
Author: Ms.Archana K Gaikwad, Mr.M.H. Dehghan
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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