Abstract: The use of cannabis for medicinal purposes is increasing globally. Numerous medical professionals express the need for additional scientific evidence concerning the use of medical cannabis. Around 50-70 per cent of the variance in cannabis use and use disorders is due to heritable factors. For cannabis use, the remaining variance can be broken down into familial and person-specific environmental factors, whereas for use disorders, only the latter factor. Numerous candidate gene studies have identified the role of common variation in cannabis involvement susceptibility, but replication has been complex. Understanding CB1 receptors raised concerns about the adverse effects of cannabis use. Consequently, the plant category has been recategorized from the medicinal category into the drug-type plants. The complexity of the cannabinoid pathway, plus individual genetic predispositions, can lead to various body responses to the cannabinoid treatment. A set of candidate genes may determine the treatment effect of the medicine based on the cannabinoid distribution and activity mechanism, as well as proteins involved in their biotransformation. No genome-wide association study has been adequately powered to identify significant loci. Despite this, research employing polygenic techniques and integrating genetic variation with neural phenotypes and measures of environmental risks, such as childhood adversity, is yielding promising new leads. The small effect sizes associated with cannabis involvement variants will only be reliably identified in significantly larger samples. Therefore, advocation for changes in public policy reflects the patient safety and efficacy of cannabis from real-world studies necessary, even though regulatory bodies have not traditionally utilized real-world evidence.
Keywords: Medical Cannabis, endocannabinoid system, cannabinoids, marijuana.
Title: Genetic Factors Associated with Medical Cannabis Treatment: Efficacy and Safety
Author: Chilita Assamakorn
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Vol. 10, Issue 1, April 2022 - September 2022
Page No: 181-186
Research Publish Journals
Website: www.researchpublish.com
Published Date: 01-August-2022
