Abstract: The use of noble metal nano particles as drugs nano carriers presents principal advantages, firstly they are able to transport several therapeutic molecules adsorbed on their surface. Penicillium chrysogenum previously known as Penicillium notatum is widely distributed in nature and is well known for it’s β-lactam antibiotics and secondary metabolites, most significantly penicillin. The current research activities synthesized the silver bio-nanoparticles from Penicillium chrysogenum by intracellular method. Nanotechnology is an emerging field, with enabling technology, the creation and application of materials, devices, and systems at atomic and molecular levels and the exploitation of novel properties that emerge at the nanometer scale. The morphological studies of the biosynthesized nano particles are done using UV-vis, SEM, & FTIR techniques. The O.D.value and spectrum was measured through UV-visible spectrophotometer. After confirmation of the formation of silver bio-nanoparticles (Ag-NPs) they were treated against different pathogenic organisms like Pseudomonas aeruginosa, Bacillus cereus, E. coli, and Staphylococcus aureus. The highest sensitive antimicrobial activities were observed in Staphylococcus aureus followed by E. coli, Pseudomonas aeruginosa and Bacillus cereus. These data constitute a preliminary study about the knowledge of the physical-chemistry properties of the drugs adsorbed on noble metal nanoparticles surface that will allow us to deep in the design of new drug delivery systems with potential to improve the clinical efficacy of the therapeutic effect.
Keywords: Penicillium chrysogenum, Bio-nanoparticles, UV–Visible Spectrophotometer, Scanning Electron Microscopy, Antimicrobial activity.
Title: GREEN SYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES AS POTENTIAL ANTIMICROBIAL AGENT
Author: S. Akila, Anima Nanda
International Journal of Engineering Research and Reviews
ISSN 2348-697X (Online)
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