Abstract: Cancer is one of the most dreadful disease affecting human as well as animals. Among all, pancreatic cancer is a common malignancy worldwide; however, reports on pancreatic cancer in livestock and pet animals are less. Azaserine is a potent pancreatic-carcinogen and Wistar rats are documented to be suitable for experimental trials on pancreatic cancer. Present study was undertaken in order to evaluate haematological changes in azaserine-induced pancreatic cancer in Wistar rats. Azaserine was administered at 5 mg/kg b.wt. intraperitoneally and haematological parameters were studied after confirmation of carcinogenesis. Reduced level of haemoglobin and total erythrocyte count (TEC) were significant alterations in haematological parameters suggestive of anemia associated with pancreatic cancer. Other haematological parameters did not reveal significant alterations.
Keywords: Haematological changes, Azaserine, Pancreatic cancer, Wistar Rats, Anemia.
Title: Haematological Changes in Azaserine-Induced Pancreatic Cancer in Wistar Rats
Author: Ankit S. Prajapati, S. K. Raval, Chirag M. Bhadesiya, B. P. Joshi
International Journal of Life Sciences Research
ISSN 2348-3148 (online), ISSN2348-313X (Print)
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