Abstract: Hepatitis B is a pernicious disease that causes liver contagion and is spread by the hepatitis B virus. It is well known to cause acute as well as chronic infection in the body and expose people to major diseases such as hepatic cirrhosis and hepatocellular carcinoma (liver cancer). To facilitate research on this virus, a multi-omics platform called HBVR (Hepatitis B Virus Repository) has been developed containing information related to the Hepatitis B virus, which specifically focuses on the genomic, phylogenetic and therapeutic study of the virus. This database comprises genome sequences as well as related functional information of the viral proteins. It renders complex analysis results such as codon usage and context, CpG islands, and phylogenetic analysis. In addition, glycosylation patterns and primers interpretation were analysed for the viral protein and genome sequences respectively. New promising candidates were predicted for therapeutically important constituents such as vaccine epitopes, small-interfering RNAs, micro RNAs, and information about the useful drug and drug targets on viral genome sequences. The therapeutic results predicted in the research further can be used to design effective hepatitis B vaccines and drugs. The repository is freely available at www.hbvr-nsut.in and is built in C#, ASP.Net Framework 4.7, and MS SQL Server 2016, with majority of the browsers supported.
Keywords: Hepatitis B Virus, Genomics, Multi-Omics Database, Phylogenetic, Therapeutic, Web Repository.
Title: HBVR: A Global Repository for Genomics, Phylogenetics, and Therapeutics Research on Hepatitis B Virus
Author: Vanshika Sharma
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
Vol. 11, Issue 1, January 2023 - March 2023
Page No: 17-26
Research Publish Journals
Website: www.researchpublish.com
Published Date: 16-January-2023
