Abstract: H. pylori infection installs a chronic inflammatory action resulting in an increased cell turnover that, over several years, might lead to an accumulation of mitotic errors, which may lead to gastric cancer by direct or indirect effect. This review aimed to discuss the role of H. pylori in the pathogenesis of gastric carcinoma, and how its most common risk factor on the risk of subsequent neoplastic transformation will also be discussed. We have conducted this review through searching the eligible articles in several databases; PubMed, and Embase, to have more evidence in the association of association between H. pylori and gastric cancer, our search was up to December 2016. And we included every study which discussed the relevant topic that our study aimed to overview. Then we limited our search to English language and only to human trails. Evidence showed a significant association between infection with H. pylori and gastric cancer, as determined by the presence of raised concentrations of IgG antibodies to the organism, and the risk of gastric cancer. The small number of cases, nevertheless, indicates that the magnitude of the odds ratio doubts. However, the association we observed is not likely to be due to opportunity and supports other evidence suggesting a causal association based upon environmental research studies,' medical observations, and what is known about the function of H. Pylori in triggering chronic gastritis.
Keywords: Helicobacter pylori, chronic inflammatory action.
Title: Helicobacter Pylori and Its Related to Gastric Cancer; Review
Author: Dina Saleh Binmahfoodh, Haneen Anees Moumina, Rahaf Mohamad Qari, Ranim Abdulbasit Andijani, Reem Jalal Alsharif, Sara Mohamed Kayal
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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