Abstract: This study was designed to evaluate the hepatoprotective effect of methanolic extract of Moringa oleifera leaves (MOLE) on the CCL4 intoxicated rats. The antioxidative effect on the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase (SOD), lipid peroxidation (MDA) and reduced glutathione (GSH) were investigated in carbon tetrachloride (CCl4) intoxicated rats pretreated with MOLE or Silymarin and α-Tocopherol. HPLC analysis of ME revealed that Ellagic acid was the most abundant phenolic compound. Pretreatment with MOLE or Silymarin significantly (P < 0.05) reduced the serum levels of AST and ALT and MDA in the liver of CCl4 treated rats. Pretreatment with MOLE increased the antioxidant activity of liver GSH. Histological analysis of liver tissues in groups pretreated with MOLE and Silymarin showed mild necrosis and inflammation of the hepatocytes compared to the CCl4-intoxicated rats.
Keywords: Hepatoprotective, liver damage, Moringa oleifera, Silymarin.
Title: Hepatoprotective Effect of Ellagic Acid Rich Extract of Moringa Oleifera Leaves on the CCL4 Intoxicated Rats
Author: Mohamed K.Abd El-Rahman, Amira Sh. Soliman, M.Khairy S.Morsi, M. A. Mehrez
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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