Abstract: The antibiotic Ciprofloxacin is routinely used by urologists, andrologist and fertility specialist to treat such bacterial infections occurring prior to in vitro fertilization treatment, or when high concentration of leukocytes are present in the semen of these patients, irrespective of microbial evidence of infection. In this study, a total of 30 rats were used. The rats were divided into control group and experimental group, the experimental group was divided into two major groups of 12 rats each i.e. therapeutic dose and double therapeutic dose groups respectively, the experimental group (group B and C) received 12.5mg/kg oral ciprofloxacin (Sigma 33433, USA) via gavage, while the double experimental group (group D and E) received 25mg/kg oral ciprofloxacin, the two experimental groups were further divided into two groups of 6 rats each i.e acute and chronic groups. The acute received corresponding dose of ciprofloxacin for 4 four weeks (28 days). The effect of ciprofloxacin was dosage dependent on the kidney. Although there was no histological changes in the renal corpuscles and renal tubules in all the groups, but the study revealed interstitial congestions which were noticed in group D and E due to the use of overdose. It is thereby recommended that prolonged usage of Ciprofloxacin should be avoided and also drug abuse and over dosage with ciprofloxacin should be avoided.
Title: HISTOLOGICAL EFFECT OF CIPROFLOXACIN ON THE KIDNEY HISTOLOGY OF ADULT RATS
Author: Uwuigbe Mathew, Idehen Iyore Charles, Airhomwanbor Kingsly, Blackie Hassan Okosun Trevor, Asibor Ernest
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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