Abstract: Breast cancer in women is a major health burden worldwide. By evaluating the bone marrow cellularity, β-esterase activity, antibody titer, plaque forming cells (PFC), serum GGT-NO levels and cellular GSH-NO levels the ethanolic extract of Phallusia nigra was assessed for immunomodulatory activity against MDA-MB-231 bearing adult Swiss albino mice. A significant, dose dependent increase in bone marrow cellularity, β-esterase activity, decrease in serum GGT-NO and cellular GSH-NO was observed. Antibody titer and PFC was maximum on 15th and 6th day of treatment respectively in group IV treated with 150 mg/kg body weight of the extract. The bioactive compounds like 2-Piperidinone, Benzeneacetamide, Tetradecanoic acid, n-Hexadecanoic acid, Phenol 3-pentadecyl, (Z,Z,Z)- phenylmethyl ester of 6,9,12-Octadecatrienoic acid, (z)-phenylmethyl ester of 9- Octadecenoic acid, Cholesterol, Cholestan-3-ol and 3-hydroxy-(3a,17a)-Spiro [androst-5-ene- 17,l’-cyclobutan]-2’-one reported as per the previous GC-MS analysis of ethanolic extract of Phallusia nigra might have modulated the immune system.
Keywords: immunomodulatory, Phallusia nigra, MDA-MB-231.
Title: IMMUNOMODULATORY ACTIVITIES OF TUNICATE-PHALLUSIA NIGRA SAVIGNY, 1816 ON MDA-MB-231 CELL LINES
Author: M. Paripoorana Selvi, V. K. Meenakshi
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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