Abstract: The immune system is involved in the etiology as well as pathophysiological mechanisms of many diseases. Modulation of the immune responses to alleviate the diseases has been of interest for many years. Thus a real need exists to protect our immune systems and lead healthier lives. Hence the present study is aimed to evaluate the immunomodulatory activity of methanolic extract of Dalbergia latifolia. The effect of methanolic extract of Dalbergia latifolia on the immune system of mice was evaluated by using different experimental models such as carbon clearance test, mice lethality test. Methanolic of Dalbergia latifolia extract was administered orally at dose of 100mg/kg and dose of 200 mg/kg. Methanolic extract of Dalbergia latifolia in both doses increased the levels of serum immunoglobulin and prevented the mortality induced by bovine Pasteur Ella multocida in mice. On the other hand, it showed significant increase in the phagocytic index in carbon clearance assay.Hence, it was concluded that methanolic extract of Dalbergia latifolia increases both humoral immunity and cell mediated immunity.
Keywords: Dalbergia latifolia; Barks, Immunomodulatory activity, Levamisole,
Title: Immunomodulatory Activity of Dalbergia Latifolia on Swis Albino Mice
Author: Dr. Nagarathna P.K.M., Saroj Kumar Yadav, Chandrajeet Kumar Yadav
International Journal of Thesis Projects and Dissertations (IJTPD)
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