Abstract: Breast cancer is ranked number one cancer among Indian females. Primary choice of treatment for cancer is chemotherapy and it is associated with toxic effects. Incidence and magnitude of adverse drug reactions (ADRs) in patients will differ accordingly. Characterizing ADRs can help in optimizing the treatment regimen.
Methods: Patients enrolled according to inclusion criteria.Assesed for incidence of ADRs and characterized the ADRs by using Naranjo Adverse Drug Reaction Probability Scale questionnaire, WHO-UMC causality assessment system questionnaire, ADR Severity Assessment Scale (Modified Hartwig and Siegel) questionnaire and ADR Preventability Assessment Scale (Modified Schumock and Thornton) questionnaire.
Result: A total of 96 patients were enrolled in the study. The most common ADR caused by Herceptin, Docetaxel, cyclophosphamide, 5- fluorouracil were Anorexia and the second most common ADR was discoloration of nail. Allergic reactions, pancytopenia and weakness were major in Epirubicin, carboplatin, Adriamycin, Paclitaxel and Gemcitabine. Majority of the ADRs were preventable, mild and possible.
Keywords: Adverse drug reactions, Chemotherapy.
Title: INCIDENCE AND CHARACTERIZATION OF ADVERSE DRUG REACIONS IN PATIENTS RECEVING CHEMOTHERAPY FOR BREAST CANCRE
Author: Alireza Agahi, Legimol PS, Binai k Sankar, Khalid PK, Pawan Gupta
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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