Abstract: Inflammatory bowel disease (IBD) has been an international health care problem with a sustained increasing incidence. It includes two significant kinds, Crohn's disease (CD) and ulcerative colitis (UC), which are distinct chronic bowel-relapsing inflammatory conditions. The aim of this review was to discuss and overview the roles of environment and diet in altering inflammatory bowel disease (IBD), also to review the etiological factors that contribute in IBD from different aspects. Electronic comprehensive search was performed through medical databases; PubMed/ MIDLINE, Embase, and science-direct, for relevant articles discussing the pathogenesis and etiology of inflammatory bowel disease (IBD), as well as studies showing the roles of environment and diet in the pathogenesis of IBD, search was to identified studies that were published through past period to December,2016, in English and containing only human subjects. The key factors responsible for IBD consist of hereditary parts, environmental elements, microbial flora and immune reactions. It is tough to dispute the common belief that IBD emerges from an extremely intricate interaction among genetic and environmental elements, dysregulated immune reactions and changes of the microbiome, and that none of these factors alone is likely to trigger the disease. Numerous patient-targeted dietary suggestions from the internet and specified diets parallel those of irritable bowel syndrome and functional food poisonings.
Keywords: IBD, Crohn's disease, ulcerative colitis.
Title: Inflammatory Bowel Disease, Etiological Factors and Role of Diet and Environment
Author: Manal Salem Alsaiari, Felwah mohammed yamani, Maram Mohammed Alyami, Wed Ahmed Al Asiri, Tagreed Hussin balhareth
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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