Abstract: 744 patients from 3 different clinical settings were evaluated as follows: unfractionated heparin (UFH) during or after cardiac surgery (n=100), UFH after orthopedic surgery (n=100, = 205) and molecular weight heparin (LMWH) after orthopedic surgery (n = 439). In the activation assay, the frequency of HIT-IgG formation varied from a minimum of 3.2% in orthopedic patients receiving LMWH to a maximum of 20% in cardiac patients receiving UFH; per antigen assay, the corresponding frequencies ranged from 7.5% to 50%.
However, in patients who developed HIT-IgG and received UFH, the probability of HIT was higher in orthopedic patients than in cardiac patients (according to the activation assay: 52.6% vs. 5%; odds ratio 21.1). [95% CI, 2.2-962.8]; P = .001; nach Antigen-Assay: 34,5 % vs. 2,0 %; Odds Ratio, 25,8 [95 % KI, 3,2-1141]; P < 001). It is concluded that there is an unexpected dissociation between the frequency of HIT-IgG formation and the risk of HIT, which depends on the patient population.
Keywords: cardiac patients, heparin-induced thrombocytopenia, patient population.
Title: Influence of the patient population on the risk of heparin-induced thrombocytopenia
Author: MOHAMMED AYED ALSEFRI, MORAD AYED ALSEFRI, ABDULLAH SALEM ALHARBI
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 10, Issue 4, October 2022 - December 2022
Page No: 82-86
Research Publish Journals
Website: www.researchpublish.com
Published Date: 22-December-2022
