Inhaled Insulin Therapy in Diabetes Mellitus

Hawra Ali Aleirani, Rasha Shaker Alkhonizi, Rawan Abdulkarim Agala, Rawan Zuhair Alqurashi, Mai Khalid Alshaikh

Abstract: Diabetes is a class of diseases characterized by elevated blood sugar in the face of inadequate insulin production or insulin action. The disease affects approximately 23.6 million Americans (8% of the population), and fully one-third of those individuals are unaware that they have the disease. There are two broad categories of diabetes – type 1 (T1DM) and type 2 diabetes (T2DM). Individuals with T1DM are dependent on insulin for survival and rely on subcutaneous administration by injection or continuous infusion. Patients with T2DM may control their disease for a time with lifestyle intervention or oral therapies. However, those who fail these strategies will require insulin to achieve adequate disease control. Delivery of insulin via inhalation is a potential alternative to subcutaneous insulin in the management of diabetes. This review will discuss the rationale for development of pulmonary delivered versions of insulin as well as discuss the role that inhaled insulin may play in improving long-term diabetes care. Keywords: Diabetes, inhaled insulin, disease, blood sugar, Patients. Title: Inhaled Insulin Therapy in Diabetes Mellitus Author: Hawra Ali Aleirani, Rasha Shaker Alkhonizi, Rawan Abdulkarim Agala, Rawan Zuhair Alqurashi, Mai Khalid Alshaikh International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Vol. 4, Issue 2, October 2016 – March 2017

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Inhaled Insulin Therapy in Diabetes Mellitus by Hawra Ali Aleirani, Rasha Shaker Alkhonizi, Rawan Abdulkarim Agala, Rawan Zuhair Alqurashi, Mai Khalid Alshaikh