Abstract: The delivery of drugs by “vesicular drug delivery system” such as nano-niosomes provides several important advantages over conventional drug therapy. Levofloxacin was selected as a suitable drug for the present study because it is a potent second generation fluoroquinolone active against a broad range of gram positive and gram-negative aerobic and anaerobic bacteria. Levofloxacin loaded nano-niosomal formulations were prepared by using different ratio of surfactant (Span 60, span 80) and cholesterol by thin film hydration followed by sonication method and was evaluated for entrapment efficiency, particle size, zeta potential, surface morphology and in-vitro drug release. Particle size and zeta potential of the F3 and F6 formulation were found to be 303.5 and 305.8 nm and -49.2 and -42.6 mV respectively. Highest entrapment efficiency was observed in F3 94% and F6 92%. The percent drug release from F1-F6 was observed as follows F1- 86.89%, F2- 74.62%, F3- 59.44%, F4- 80.59%, F5-72.46% , and F6- 55.8% which follows zero order drug release and Non- Fickian diffusion mechanism.
Keywords: Levofloxacin, nano-niosomes, tuberculosis, thin film hydration method, in-vitro study, stability study.
Title: Levofloxacin Loaded Nano-Niosomes for Effective Treatment of Tuberculosis
Author: Ranjini D S, Parthiban S, Senthil kumar G P, Tamizh Mani T
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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