Abstract: Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis. Indonesia ranks third in the world as the country with the most tuberculosis cases. Bacteriology is the standard of examination for the diagnosis of tuberculosis. Culture examination takes a long time, TCM must use a sputum sample and special examination tools. Interferon-γ release assays immunological examination (IGRA) is quite expensive and requires special equipment. Hematological examination can be used as an option for supporting examination in establishing the diagnosis of tuberculosis by immunology. The purpose of this study is a journal review to identify the potential (MLR) Monocyte Lymphocyte Ratio as a support in diagnosing tuberculosis. Article searches were conducted online from the NCBI, PubMed and Science Direct databases. Sorting articles using the PRISMA flow. Finally, eligible articles were selected based on the criteria for patient, intervention, comparison, outcome, and study (PICOS), namely tuberculosis patients, MLR, tuberculosis diagnosis, and the original study. The results of this study obtained seven articles from the initial number of 9,234 articles found from key words. Two of the seven articles stated that MLR could be used as a support for the diagnosis of tuberculosis. Two articles stated that monocytes and lymphocytes could be markers of bacterial infections including tuberculosis. One article mentions the association of tuberculosis with decreased production of monocyte and lymphocyte cytokines. Two articles stated that MLR was not associated with tuberculosis cases. One article mentions the MLR value limit of 0.378 to support the diagnosis of tuberculosis. Observational research on MLR to support the diagnosis of tuberculosis in Indonesia still needs to be done, especially the assessment of the MLR value limit.
Keywords: Diagnosis, hematology, lymphocytes, monocytes, MLR, tuberculosis.
Title: Meta-analysis: MLR (Monocyte Lymphocyte Ratio) as the Examination of Choice in Diagnosing Tuberculosis
Author: Agus Wahyu Permana, Dewi Arimas Ni Made
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Vol. 10, Issue 2, October 2022 - March 2023
Page No: 1-6
Research Publish Journals
Website: www.researchpublish.com
Published Date: 03-October-2022
