Abstract: We herein represent the modifications of synthesis and easy isolation of new 1,2,4-oxadiazoles from the corresponding amidoximes were treated with the carboxylic acids followed by the cyclodehydration in p-xylene in the presence of 0.1 equivalent of 1,8-Diazabicyclo[5.4.0] undec-7-one (DBU) afforded in 80-96% yield. All the final compounds were isolated followed by purification with Dimethyl sulphoxide (DMSO) and Methanol (MeOH) and the review to the synthetic methodologies. This robust purification protocol and modified process is applicable for the bulk production in the pharmaceutical industry.
Keywords: Amidoximes, Carboxylic acids, cyclodehydration. 1,2,4-oxadiazoles and DBU.
Title: Modifications to the process for the synthesis of new 1,2,4-oxadiazole analogues and the short review on synthetic methodologies of 1,2,4-oxadiazoles
Author: Senthil Periyasmay, Selvaraj Subbiah
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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