Abstract: Free radicals are capable of damaging cellular molecules, DNA, proteins, and lipids leading to altered cellular functions. Many recent studies reveal that antioxidants capable of neutralizing free radicals are effective in preventing experimentally induced diabetes in animal models [1] as well as reducing the severity of diabetic complications. The aim of this study is to investigate modulation of diabetic complications by lycopene alone or combined with linolenic acid in diabetic rats. Sixty male Wister rats were used in this experiment. Divided into 6 groups (each 10 rats) . (group 1, normal), which was receive a single dose of 0.1 mol/L citrate buffer intrapertnial. (Group 2-6) rats were intrapretonial injected with STZ (65 mg/kg body weight) [7],STZ was freshly prepared in a 0.1 mol/L citrate buffer (pH 4.5).Only rats with blood glucose higher than 250 mg/dL after 5 days will be considered as being diabetic in the fasting state, diabetic rats were randomly divided into 5 groups: healthy group were received 0.1mol/l citrate buffer, Diabetic untreated , and three groups ,diabetic and treated with two different types from the extract lycopene and linolenic acid and third group treated with combination of both above mentioned. Treatments will be continued for 6 weeks. Oxidative stress markers (Nitric oxide, malondialdhyde, glutathione peroxidase and lactate dehydrogenase) were evaluated in all groups.It was found that, Lycopene alone or combined with linolenic acid acts as free radical scavenging system that protect the damage of complications of diabetic. Further studies should be done to examin the signaling of diabetic and the action of these nutrients as antioxidant.
Keywords: Diabetic complications- rats- Lycopene.
Title: Modulation of Diabetic Complications by Lycopene and Linolenic Acid in Rats
Author: Yousef A. D. AL-Khadem, Abdulrahman L. AL-Malki, Said S. Moselhy
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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