Abstract: In comparative protection against Pasteurella multocida infection in rabbits evaluated by compare the efficacy of mucosal immune response to systemic immune response. Rabbit groups were immunized intranasally and subcutaneously with a bacterin vaccine and cell lysate of P. multocida serotype B: 2. Mucosal protection in rabbit groups immunized intranasally with the bacterin and cell lysate was measured by the indirect haemagglutination testing of nasal lavages. Subcutaneous immunization of rabbits with the two vaccines induced protection in rabbits. The protection was demonstrated in serum samples collected from immunized animals and examined for antibody titer by the indirect haemagglutination test IHA. Protection of immunized rabbits was further proved by challenge inoculation of the animals with viable P. multocida. The survival rate in all subcutaneously vaccinated group was 100%. While the survival rate in intranasally immunized groups was 100%, and 75% with bacterin and cell lysate respectively. This study concluded that immunization of rabbits intranasally with P. multocida induces an effective protective immune response against P. multocida.
Keywords: P. multocida; immunity; rabbits; vaccine; adjuvant.
Title: MUCOSAL VERSUS SYSTEMIC IMMUNITY AGAINST P. MULTOCIDA INFECTION IN RABBITS
Author: Mortada. M. Yagoub, K. M. Suleiman
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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