Abstract: 3,4-dihydropyrimidin-2-(1H)-ones were synthesized in high yields through Biginelli condensation reactions of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using Nickel (II) perchlorate as a catalyst under solvent-free conditions. Readily available reagent, inexpensive and eco-friendly catalyst. This method provides the modified synthesis of biologically active compounds such as much Nifedipine and Amlodipine, in terms of high yield, short reaction time and simple workup procedure.
Keywords: Nickel perchlorate; Biginelli reaction; solvent-free; dihydropyrimidinones; one-pot condensation.
Title: Ni (ClO4)2.6H2O an Efficient Catalyst for One-Pot Synthesis of Dihydropyrimidinones
Author: Muralidharan S, Rajasekhar M
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
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