Abstract: Noonan syndrome (NS) is a common genetic condition with multiple congenital abnormalities, characterized by high incidence of congenital heart disease, facial anomalies, webbed neck, cryptorchidism, behavioural problem, hearing loss and other comorbidities. The cause of this disorder is believed to be mutations of RSA/mitogenactivated protein kinase (MAPK) pathway. Diagnosis can be achieved by the basis of clinical features although it has similarities to patients who have Turner syndrome. A number of cases with features of NS reported with multiple or solitary central giant cell granuloma (CGCG). This report aims to present a case of 14-year-old Saudi patient with NS associated with recurrent CGCG.
Keywords: Noonan syndrome, Giant cell granuloma, PTPN11.
Title: Noonan Syndrome with Recurrent Central Giant Cell Granulouma
Author: Majeda Alslimi, Amjad Almalki, Abdulrahman Alissa
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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