Abstract: Autophagy is a cellular self-degradation system that transfers cytoplasmic components to the lysosome by means of autophagosome. A wide array of molecules has been linked to the formation of this structure. LC3, a structural protein of autophagosome membrane, is widely studied protein among others, due, mainly, to its participation at different stages of autophagy. For the same reason, it has been successfully used as a biomarker of autophagy. Recent progress has demonstrated LC3 cycling between nucleus and cytoplasm in an autophagic-dependent manner. In this regard, some intracellular mechanisms have also been proposed that underline nucleocytoplasmic shuttling of LC3, such as protein-protein interaction and deacetylation/ acetylation reaction. The aim of this review is to discuss the distribution of LC3 in the nucleus and cytoplasm in the light of recent findings, and highlighting pathways regulating LC3 shuttling.
Keywords: Autophagy, LC3, Nucleocytoplasm, Nucleus, Cytoplasm, Dispersal.
Title: Nucleocytoplasmic Dispersal of Autophagosome Marker LC3
Author: Rawaz Sulaiman
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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