Abstract: Systemic mastocytosis (SM) constitutes a stem cell-derived clonal myeloproliferation with obvious mast cell expansion. Medical symptoms include urticaria pigmentosa and mast cell arbitrator release signs (MCMRS) such as anaphylaxis, diarrhea, and presyncope. This review aimed to discuss and evaluate the diagnosis approaches of Systemic mastocytosis also to be able to clear the concepts of diagnosis of this stem cell disorder, we therefore reviewed the clinical manifestations of mastocytosis. PubMed, and Embase databases searches were performed for articles published regarding diagnosis procedures of systemic mastocytosis and the diagnostic criteria and treatment options for this condition using the keywords: systemic mastocytosis, mastocytosis prognosis, World Health Organization diagnostic criteria, management, diagnosis, retrieved articles were surveyed for additional citations. The method to adult patients with presumed mastocytosis is a diagnostic obstacle in daily practice, particularly when the doctor is unaware of the biology and etiology of the disease, no skin lesions exist, blood counts are normal and the serum tryptase level is slightly elevated or within typical range. The KIT anomaly analysis (KIT D816V) in the peripheral blood is a necessary pre-invasive test in these patients. A favorable test outcome is suggestive of the existence of SM, with all clinical consequences, including a bone marrow biopsy.
Keywords: Systemic mastocytosis (SM), mast cell arbitrator release signs (MCMRS), KIT anomaly analysis.
Title: Overview of Diagnostic Procedure of Systemic Mastocytosis
Author: Ali Abdulrahman Saad Alghamdi, Yousif Abdullah Ahmed Alsaggaf, Aisha Abdulwadod Abdulmughi Algaradi, Hussain Mohammad Alqurashi, Waleed Khalid A Nawwab, Abdulrahman Naif A Qutub, Saad Mustafa Saad Alharbi, Aiman Mohammed Alshomrani
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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