Overview of Fragile X Syndrome, Causes and Impact on Quality of Life

Abstract: Present study was conducted to determine the etiological factors which contribute in the pathogenesis of Fragile X syndrome (FXS), which is mostly genetics factors, and to evaluate the quality of life among those FXS patients. We conducted this review paper by performing a search strategy among medical databases such MIDLINE, science-direct, from the instance time to 2016, including only studies published in English language and with human subjects only. studies that demonstrate the genetics factors as a cause of FXS were included, in addition to those discussing the impact of FXS on quality of life on patients and their families. Fragile X syndrome (FXS) is the most frequent type of acquired intellectual special needs and is likewise linked to other neurologic and psychiatric conditions. While the molecular functions of FMRP are still being marked, FMRP is mainly developed to function in regulating mRNA metabolic process in brain. The wide variety of putative mRNA targets and several FMRP-interacting proteins with overlapping function might describe the large and variable physical phenotypes observed in FXS. FXS care needs substantial resources that are primarily non-medical in nature and are higher for children than for adults. Compared with associated diseases, FXS makes up an especially high problem for caretakers. Keywords: Fragile X syndrome (FXS), medical databases, MIDLINE, FMRP, children than for adults. Title: Overview of Fragile X Syndrome, Causes and Impact on Quality of Life Author: AlSHEBANA, NOORA ABDULAZIZ H, ALROWAITHI, BASSMAH HASSAN M, AlROWATHI, KHLOOD IBRAHEEM H, ALGHAMDI, RAHAF ABDULLAH R, ALGHAMDI, AFNAN ALI S International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

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