Abstract: The aim of this review was to discuss the Gaucher disease from different aspects, and highlight the treatment options for the symptoms and consequences following this disease. Comprehensive computerized review was conducted using several databases such; Medline, PubMed, Embase, to find relevant studies published up to March,2017, discussing the treatment options of Gaucher disease, we limited our search for English language articles, and references lists of those articles were reviewed for more relevant studies that could have support our review. Oral medicine that inhibits glucosylceremide synthase (substrate reduction treatment) as well as may partially raise glucocerebrosidase enzyme task (chaperone mediated treatment). Research studies showed that miglustat did boost the biochemical end results of patients with mild to moderate type 1 Gaucher during clinical trials varying from 6 to 36 months, however there wants proof to show if treatment will maintain both professional and also biochemical results over a long-term duration, or on its performance in dealing with the bones and preventing severe elements such as pulmonary hypertension.
Keywords: Gaucher disease, symptoms, treatment, biochemical results, pulmonary hypertension.
Title: Overview of Gaucher Disease, Consequences and Treatment Options
Author: Feras Khalid Mimarji, Redwan Muneer Fargal, Ali Hassan Busanah, Mojahid Ibrahim Ghazi, Hussain Abdulillah Iraqi, Ahmed Faisal Basalam, Abdulrahman Mohammed Hamzah
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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