Abstract: In this review, we aimed to look at the new pathomechanism, dysfunction and management of macrophage activation syndrome. Our aim is to summarize the progress in understanding of MAS pathophysiology, show the symptoms that can help find specific diagnostic method. A systematic literature search was performed in MEDLINE, EMBASE and Cochrane. Our computerized search strategy with English language restriction was conducted on literature of the past 25 years. Macrophage activation syndrome is a life-threatening complication seen predominantly in children with systemic onset juvenile idiopathic arthritis. It accounts for a significant amount of the morbidity and mortality, it is essentially important to recognize and treat MAS earlier in order to lower the mortality. There are still no validated diagnostic criteria and early diagnosis is difficult. Further immunological and genetic studies are needed in larger cohorts of patients in order to better understand the pathophysiology of MAS.
Keywords: pathophysiology of MAS (Macrophage Activation Syndrome).
Title: Overview of Macrophage Activation Syndrome in Children
Author: Abdulaziz Obayed S. Algumaan, Mohammed Omar Alomar, Mugbil Saad S. Aljaman, Ahlam Falah M. Alotaibi, Nourah Ali A. Homaily, Mashael Abdulaziz I. Alawad, Ahmed Saeed H. Alqahtani, Sukainah Hussain S. Alabkary
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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