Abstract: Present study goal was to review the evidence about pathogenesis, diagnosis, and treatment approaches for Addison disease or as its also called primary adrenal insufficiency. PubMed, Medline, and Embase databases were comprehensively searched for relevant articles reporting Addison disease treatment options, pathogenesis and other different clinical aspects concerning this disease, with human subjects and only articles published in English language up to December, 2016. The cutaneous manifestations include darkening of the skin especially in sun-exposed areas and hyperpigmentation of the palmar creases, frictional surfaces, vermilion boundary, current marks, genital skin, as well as oral mucosa. The 250 μg ACTH stimulation examination supplies the medical diagnosis of adrenal insufficiency in the majority of patients. Dimension of totally free lotion or salivary cortisol could be useful when CBG is reduced, yet calls for standardization. Adrenal deficiency is connected with lowered lifestyle that may be caused by non-physiological glucocorticoid substitute.
Keywords: pathogenesis, diagnosis, treatment, frictional surfaces, vermilion boundary, genital skin.
Title: Overview of Pathogenesis and Treatment Options of Addison Disease
Author: Abdulrahman Hussain Haddad, SAWSAN MOHAMMED ABU HADI, Abeer Abdalaziz Alhatem, Abdulrahman Saad Albakheet, Saad munawwikh alshammari, Salman jubran farhan almalki, Sultan jubran farhan almalki, Fatima Ali Albinalshikh, Sultan jaber m alfaifi, Muataz Ibrahim Alnami, AL MARAIH IBRAHEEM FARA M, ABDULLAH YAHYA AL JAMAHIR, Abdulrahman A bubakr Sharwani
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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