Overview of Pathogenesis Rheumatic Heart Disease and its Proper Management

Abstract: Rheumatic heart disease (RHD) is cardiac inflammation and scarring activated by an autoimmune response to infection with group A streptococci. In the intense phase, this condition consists of pancarditis, including inflammation of the myocardium, endocardium, and epicardium. Chronic disease is manifested by valvular fibrosis, leading to stenosis and/or insufficiency. This review provides an overview of the current evidence of pathogenesis of RHD, and we also intended to discuss the treatment approaches and prevention that can be taken in advances to avoid RHD. Very detailed search of the literature about Rheumatic heart disease was performed among following databases; PubMed/MIDLINE, and Embase for all relevant articles which were published until December, 2016. We specifically search for studies that are discussing the management and pathogenesis of RHD, we restricted our search for only English language publish articles with human subject.Cytokines play an essential role in inflammation and regulation of immune reaction in RF/RHD and IL-10 gene polymorphism might explain genetic predisposition in RHD patients. Specific medical treatment to manage or prevent heart damage and main prevention of RF continue to be evasive. Main prevention has to depend upon creating a vaccine to prevent GAS infection related suppurative as well as non-suppurative disease manifestations. Keywords: Rheumatic heart disease. Title: Overview of Pathogenesis Rheumatic Heart Disease and its Proper Management Author: Mohammed Hussain fatani, Mohammed Ghazi Humud Alharbi, Hussain Ali Alaidarous, Jawzaa saleh allehyani, Abdalrhman Hussain Fatani, Marwan Hussain Alhazmi, Abdullah Mohammed Alasiri, Nuha Hazem Bukhari International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Citation