Abstract: Maternal alloimmunization, likewise referred to as isoimmunization, happens when a lady's body immune system is sensitized to foreign erythrocyte surface area antigens, stimulating the production of immunoglobulin G (IgG) antibodies. We aimed by this review to emphasize the important and procedures which are done to prevent and to manage the Rh alloimmunization in pregnancy, we also aimed to discuss the complications that can occur in relation to this condition. The Embase and MEDLINE databases were searched for English-language articles to November 2016, relating to the prevention of Rh alloimmunization. Searching done using following terms: “Rho(D) immune globulin”, “Rh iso- or allo-immunization”, “anti-D, anti-Rh” together with other secondary terms which are: “pregnancy” and “prevention” and “Treatment”. Many scientific scenarios showed that the several factors can cause a Rh D-negative female to become alloimmunized. Of Rh D-negative women who do not receive RhoGAM during pregnancy, 17% will become alloimmunized; 90% of these cases can result from fetomaternal hemorrhage at delivery; 10% can arise from antenatal fetomaternal hemorrhage. Other evidence from our review stated that the quantity of blood had to become alloimmunized is tiny; a fetomaternal hemorrhage of less than 0.1 mL is all that is needed. Decreased incidence of Rh alloimmunization and decreased practice variation with regards to immunoprophylaxis strategies.
Keywords: alloimmunization, immunoprophylaxis, “Rho (D) immune globulin”, RhoGAM.
Title: Overview of Prevention and Management of Rh Alloimmunization in Pregnancy
Author: Enas elsayed sharaf Khalil, Ahmed reyad elrify, Emad mohammed ghafori, tariq faruk kurdi
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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