Abstract: Sickle-cell disease is a multisystem disease, associated with episodes of intense disease and progressive organ damage, and is among the most typical serious monogenic conditions around the world. We searched Medline, Embase, and Google scholar for Literature about SCD through 2016, for English, using key words included individual use or a combination of the following: “Hydroxyurea or HU or hydroxycarbamide”, “Foetal hemoglobin or HbF or gamma globin”, “hemoglobin-induction”, “Sickle Cell disease”, “SCD treatment” primary publications that described treatment in humans. The majority of people with sickle-cell disease reside in Africa, where little is understood about this disease; nevertheless, we do understand that the condition follows a more extreme medical course in Africa than for the remainder of the world which transmittable illness have a function in triggering this increased seriousness of sickle-cell disease. Hydroxyurea (HU) treatment has actually shown success in numerous settings, both in children and grownups with SCD. hydroxyurea is the only easily offered representative that enhances both scientific and hematologic outcomes. It’s understood and possible toxicities must be interpreted in this context, due to the fact that it is suggested for dealing with a disease with incredible morbidity and early death.
Keywords: Sickle Cell disease”, “SCD treatment, Hydroxyurea or HU or hydroxycarbamide.
Title: Overview of Sickle Cell Disease (SCD) and the Efficiently of Hydroxyurea for Treating Patients with Sickle Cell
Author: FAISAL ABDULLAH HABIB, ALSHAHRANI, MOHAMMED SALEH M, ABDULLAH SAAD ALASMARI, ALASMARI, MESHAL ALI S, ASIRI, SAAD ALI M
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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