Abstract: In this review we are going to discuss the underlying mechanisms of thalassemia in children. We aimed to determine the renal abnormalities in thalassemia patients, to outline types and diagnosis. We conducted a literature review of articles published up to 2017, in following databases; PubMed, and Embase overviewing the thalassemia in children. The thalassemias are a group of anemias that outcome from inherited defects in the generation of hemoglobin. Renal hyperfiltration, hypercalciuria, and albuminuria are usual in thalassemia patients. Higher transfusion intensity is associated with lower creatinine clearance but more frequent hypercalciuria. Patients with Beta thalassemia significant (β-TM) typically existing early in life with extensive anemia that demands normal blood transfusion to endure. Duplicated blood transfusions are certainly connected with iron overload that results in several body organ disorders particularly heart, liver as well as endocrine glands.
Keywords: thalassemia patients, diagnosis, children.
Title: Overview of Thalassemia in Children, Renal Complications
Author: Mona Abdullah Alharbi, Zainab Habib M Alnakhli, Menal Mehmet Dogan, Reham Nasser Al AKbani, Rahaf Abdullah AlSharif, Mariam khalid Al-Daie, Shaima Ruwayshid Alhazmi, Abdulrahman Saad Albakheet, Abdullah Mosfer Alelyani, Rani naser Abumansour
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
