Abstract: Evaluation of the effect of the antioxidants lack on the level of oxidative stress and to find out if there is any increased susceptibility to atherogenesis.
Patients and methods: Twenty Egyptian patients with β-thalassemia were recruited from the outpatient clinic of Clinical Genetics Department, National Research Centre and twenty healthy subjects as a control group.This study was approved by the Ethics Committee.
Results: In beta-Thalassaemia patients had a significant decrease in the mean of Paraoxonase1, Arylesterase, Reduced Glutathione and Catalase (p<0.01) activities along with a significant increased malondialdehyde (MDA) (p<0.01) level. Cholesterol, HDL-cholesterol, LDL-cholesterol levels were found to be significantly lower (p<0.01, p<0.05 and p<0.01 respectively), while the triglyceride level was found to be significantly higher (p<0.01) in patients with Beta-Thalassemia major than in the control group.
Conclusion: Beta-Thalassaemia patients are mainly exposed to higher oxidative stress of reactive oxygen intermediates due to iron overload hence, they had decreased antioxidants level (Paraoxonase 1, arylesterase , reduced glutathione and catalase) along with hypertriglyceridaemia, hypocholesterolemia ,low HDL-cholesterol levels and also increased malondialdehyde level. so that all these factors contributing to the development of atherosclerosis.
Keywords: Beta-Thalassaemia- Oxidative stress- Atherosclerosis –Paraoxonase 1- Arylesterase- Reduced glutathione-Catalase- Malondialdehyde .
Title: Oxidative Stress Damage and Risk of Atherosclerosis in Beta-Thalassemia Patients
Author: Mohsen Rageb Tolba, Nabil Abbas Ahmed Soliman, Ghada yousef El-Kamah, HalaBassyouni El-Tabie , Sawsan MohammedAbd Al-Hamid,Amira Ibrahim EL-Shehaby
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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