Abstract: Evaluation of the effect of the antioxidants lack on the level of oxidative stress and to find out if there is any increased susceptibility to atherogenesis.
Patients and methods: Twenty Egyptian patients with β-thalassemia and twenty healthy controls were recruited from the outpatient clinic of Clinical Genetics Department, National Research Centre. Twenty healthy Egyptian were used as controls. This study was approved by the Ethics Committee.
Results: In beta-Thalassaemia patients had significant decrease in mean of Paraoxonase1, Arylesterase, Reduced Glutathione and Catalase (p<0.01) activities along with significant increased malondialdehyde (MDA) (p<0.01) level. Cholesterol, HDL-cholesterol, LDL-cholesterol levels were found to be significantly lower (p<0.01, p<0.05 and p<0.01 respectively), while the triglyceride level was found to be significantly higher (p<0.01) in patients with Beta-Thalassemia major than in the controls.
Conclusion: Beta-Thalassaemia patients are mainly exposed to higher oxidative stress of reactive oxygen intermediates due to iron overload hence, they had decreased antioxidants level( Paraoxonase 1, arylesterase , reduced glutathione and catalase) along with hypertriglyceridaemia, hypocholesterolemia ,low HDL-cholesterol levels and also increased malondialdehyde level. so that all these factors contributing to the development of atherosclerosis.
Keywords: b-Thalassaemia- oxidative stress- atherosclerosis –Paraoxonase 1- arylesterase- reduced glutathione-catalase- malondialdehyde .
Title: Oxidative Stress Parameters in Beta-Thalassemia
Author: Mohsen Rageb Tolba, Nabil Abbas Ahmed Soliman, Ghada yousef El- kamah, Amira Ibrahim EL-shehaby
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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