Abstract: Crohn's disease (CD) is characterized by chronic relapsing inflammation of the gastrointestinal tract. The precise systems associated with the event and advancement of inflammatory bowel disease (IBD) stay uncertain, however several elements might be clear. Of these aspects, immunological dysfunction combined with intolerance to the intestinal plants, specifically in genetically prone patients, appears to have crucial impacts in the pathogenesis of CD. we aimed to provide an overview of pathogenesis of CD through literature review of previous studies. Indicate the genes are discussed in the relevant pathways, as well as how these molecular pathways interact with environmental factors to modulate intestinal homeostasis. And finally we discuss the optimal treatment approaches for CD. We searched the PubMed, Medline, Web of Science, and Embase databases using keywords that denote Crohn's disease or inflammatory bowel diseases were searched from the time of their establishment to October 2016 using the following search terms: antibiotics, Crohn’s disease (CD), and inflammatory bowel disease (IBD). Genetic predisposition to Crohn's Disease may be associated with response to therapy or may serve as a factor for design more effective personalized therapy. About 70 loci are associated with susceptibility to Crohn's disease development, particularly in pathways of innate immunity, autophagy, and pathogen recognition. A multilocus approach using autophagy-related genes provides insight into CD phenotype–genotype associations and genetic markers for predicting therapeutic responses.
Keywords: Crohn's disease (CD), inflammatory bowel disease (IBD).
Title: Pathogenesis and Roles of Treatment of Crohn's Disease (CD): Systematic Review
Author: AHMED MOHAMMED ALABDULSALAM, ABDULAZIZ ABDULLAH ALHAQBANI, ALI ABDULLAH ALGARNI, MUATH SALMAN ALMUHAINI, SAAD ABDULAZIZ ALHUWAIMEL
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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