Abstract: Crohn’s disease (CD) and ulcerative colitis (UC) are the two main forms of chronic inflammatory bowel disease (IBD). The aim of this successful updated review study was to overview the pathogenesis of Crohn’s disease (CD) and ulcerative colitis, and demonstrate the most updated evidence in this topic, we also aimed to discuss the treatment of both diseases. PubMed and Embase were searched for eligible studies that discussing the pathogenesis background of the most common two inflammatory bowel diseases (CD&UC) up to November 2016, search strategy used MeSH ⁄ EMTREE terms and free text words, and included sub-searches related to the index test, target condition, study population and publication type. The etiology is complicated, the most extensively accepted hypothesis purports CD as an immune-mediated condition in genetically vulnerable people, where disease onset is set off by environmental aspects that irritate the mucosal barrier, alter the healthy balance of the gut microbiota, and unusually stimulate gut immune responses. If an individual has a genetic susceptibility to infections, the down guideline of a swelling in the bowel wall does not happen in an appropriate method. This initiates the auto-immune process which is a self-increasing cycle. Extra-intestinal manifestations of IBD are of high significance due to the fact that they cannot just follow intestinal signs, but precede them by years.
Keywords: Crohn’s disease (CD), ulcerative colitis (UC).
Title: Pathogenesis of Crohn's Disease and Ulcerative Colitis; Systematic Review
Author: Abdulaziz Mahmoud Dwaib, Abrar Saeed Baraweih, Ahmad Abdulmajeed Abed, Amal Saeed Alamoudi, Faisal Abdullah Aljedani
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
