Abstract: Diabetes Mellitus is one of the most common diseases in the world, affecting millions of peoples every year, one of its most serious complications is diabetic neuropathy and the associated neuropathic pain resulting from various causes within the body of a diabetic patient, most commonly it is the nerve damage that causes this pain due to over accumulation of glucose in the body, but this is not the sole reason for pain generation. In this review article, different factors causing the pain in diabetic patients is discussed alongside with pathogenesis of diabetic neuropathy to understand the mechanism of pain generation and it treatment options based on gene therapy techniques dealing with pain generation and sensation on cellular and molecular basis. Gene therapy is a modern revolutionary technique aiming at treating the cause of the pain rather than masking the pain sensation like conventional therapy techniques do, however, gene therapy is a novel technique which is still not fully developed and still have a number of challenges and limitations regarding its safety, effectiveness and cost.
Keywords: Neuropathic Pain, Gene Therapy, Diabetes Mellitus, Diabetic Neuropathy.
Title: Pharmacological approach for the treatment of diabetic neuropathic pain: A Control of discomfort using gene therapy
Author: Yousif Safaa Aldeen Subhi Al Daghestani, Faruk Yusuf, Manish Kumar, Indu Melkani, Bimlesh Kumar, Linu Dash, Anupriya, Varimadugu Bhanukirankumar Reddy, Amrik Singh, Amarish Kumar Sarma
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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