Abstract: For several years plants have been a source of potential drug substance which has been a resurgence of interest to researchers for natural materials as an alternative for the treatment and management of many diseases. Datura metel is a member of the family Solanaceae, shrub-like annual herb known as devil's trumpet. Pain is a devastating health problems commonly treated with traditional medicinal plants in many part of the world most especially in Africa, because of the high cost of some drugs; some have turn to consuming of plants materials to reach their desire. The roots of Datura metel have been used as pain resistant during traditional marriage rights, as such; its analgesic effect needs to be investigated for its claim. The root of Datura metel was extracted by cool maceration using methanol. Phytochemicals were screened using laboratory methods. The phytochemical screening of methanolic root extract revealed the presence of bioactive constituents such as alkaloids, flavonoids, tannins, saponins, terpenoids, phenols and steroids while glycoside and anthraquinones were absent. Thirty albino rats were used to assess the analgesic activity of Datura metel and were divided into six groups of 5 rats each. The extract was potent at all doses as well as the standard drug when compared with negative control. From the results obtained, it can be concluded that methanol root extract of Datura metel could be used as a pain reliever in traditional medicine. This validates its analgesic and is recommended for use in analgesic formulations.
Keywords: medicinal, plant, Datura, root, pain, analgesic, rats and methanol.
Title: PHYTOCHEMICAL ANALYSIS AND ANALGESIC ACTIVITY OF METHANOL ROOT EXTRACT OF DATURA METEL USING ALBINO RATS
Author: A. Gana, Y. Haruna, C.M. Elinge, A. Attahiru
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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