Abstract: Haemopoietic effects of crude methanolic extract of Dacryodes edulis (D. edulis) seeds was investigated in Wistar rats. Wistar rats (n=28), were grouped into 4 of 7 rats per group, labeled A-D. Groups A-C were orally administered with graded-doses of the extract (A=100, B=200 and C=300) mg/kg bodyweight respectively daily for 30 days. Group D served as control. Blood samples (2.0 ml) were collected from each rat through the retro orbital plexus of the median canthus into K3-EDTA containers for haematological analysis. The results revealed significantly decreased mean Hemoglobin (Hb) [g/dl]: (A=11.2±1.2, B=11.9±1.9, C=10.8±1.0), Haematocrit (Hct) [L/L]: (A=0.32±0.02, B=0.33±0.03, C=0.31±0.04) and significantly increased mean Total WBC (TWBC) [x109/l]: (A=6.55±0.2, B=7.73±0.43, C=8.10±0.35) and platelets [x109/l]: (A=961.67±11.2, B=988.55±23.8, C=1009.35±15.3) compared to control (Hb=15.4±1.3g/dl, Hct=0.43±0.03L/L, TWBC=4.85±0.15 x109/l, Platelet=570.25±10.1x109/l, (P=0.05). This study revealed decreased Hb and Hct and increased TWBC and platelets after oral administration of graded-doses of D. edulis seeds extract in Wistar rats.
Keywords: Haemopoietic, Dacryodes edulis, Graded-doses, Oral, Wistar rats.
Title: Potential Haemopoietic Effects of Dacryodes Edulis Seeds Extract in Wistar Rats
Author: Silas Ufelle, Ernest Ukaejiofo, Peter Achukwu, Blessing Eluke, Samuel Ghasi, Emeka Neboh
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
