Abstract: This prospective cross-sectional study was conducted during the period between March 2015 and October 2016.
Objective: to investigate the reliability of cyclic citrullinated peptide reactive antibodies (Anti-CCP) as a predictive tool for detection of early-undifferentiated Rheumatoid Arthritis (RA) in first-degree relatives of patients with RA in Khartoum state, Sudan.
Methods: Four hundred serum samples were drawn from individuals in the study, aged between (17-40 years) without symptoms of RA were enrolled, Anti-CCP levels were estimated using Enzyme Linked Immune Sorbent Assay (ELISA) while Rheumatoid Factor (RF) tested in the serum from each individual using Beckman culture Au 480, and Statistical Package for Social Science (SPSS version 22) computer software was used for data analysis.
Results: of study indicates that Anti-CCP test has a predictive value in first-degree relatives of RA patients without presence of RA diagnostic criteria.
Conclusion: emphasized that Anti-CCP test has predictive value when used in investigating early presence of RA within the same family on specific populations who are considered as risk group (first degree relatives of patients) due to sharing genetic and environmental properties .The current study recommends to run Anti-CCP on first degree relative of patients with RA as an early diagnostic tool.
Keywords: Predictive Value, cyclic citrullinated peptide, Rheumatoid Arthritis (RA), Anti-CCP.
Title: Predictive Value of Cyclic Citrullinated Peptide Reactive Antibodies in Diagnosis of Early-Undifferentiated Rheumatoid Arthritis in Families with History of Rheumatoid Arthritis
Author: Mohannad Gaiballa Mohammed Abdelgader, Abu Elgasim Mohamed Ali Musa, Samia Elhaj, Sayed Ibrahim Ali
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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