Abstract: Polyurethane (PU) is a dressing agent with high absorption and moisture permeability and has excellent wound healing effects. Silk fibroin (SF) is an attractive biomaterial as per clinical studies. In this study, a novel PU series was synthesized using bio-based isosorbide and SF at different ratios. The successful synthesis of the PU-SF series was confirmed by Fourier transform-infrared spectroscopy. The wettability of the polymer surface was evaluated based on the contact angle. The thermal properties were determined by thermogravimetric analysis to evaluate the thermal stability. The mechanical properties of the PU-SF series were evaluated using an Instron universal testing machine. The addition of SF significantly improved the tensile properties of the PU-based material. The mouse myoblast cell line C2C12 was used as a model for in vitro experiments with the PU-SF series to ensure biocompatibility and non-toxicity; the cell response improved with increasing SF content. The PU-SF series shows significant potential for specific regenerative medicine applications due to its biocompatibility and good physical properties, including in wound dressing.
Keywords: Polyurethane, silk fibroin, wound dressing, isosorbide, biocompatibility.
Title: Preparation and Properties of Biocompatible Polyurethane based on Isosorbide and Silk Fibroin
Author: Sarah Kim, Jong-Wan Kim, Jae-Ryung Cha
International Journal of Engineering Research and Reviews
ISSN 2348-697X (Online)
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