Abstract: The study to assess the prevalence of ESBL-producing organisms in the South-South geopolitical zones of Nigeria was investigated. Clinical specimens of urine, stool, sputum, blood, high vaginal swabs, wound, pus and urinogenital swabs were obtained from health resource centers in Akwa Ibom, Cross River State, Delta Edo and Rivers States, all in South-South geopolitical zone of Nigeria. Double disk synergy test (DDST) was used to detect ESBL production. Quick identification was confirmed using Ceftazidime. Inositol Amphotericin B Agar (CIVA). Results from the study revealed that a total of 130 (20.1%) isolates were positive for ESBL production. Delta State had the highest percentage occurrence of 30.5% and Rivers State was least with 9.4%. Urinogenital swab had the highest production for ESBL with 31(27.2%). Results of fitting logistic regression in univeriate and multivariable analysis revealed significant association of ESBL production with Isolate type (p<0.001) and States (p<0.0001). No association was observed for Source (p-value 0.60) and Patient location (p-value = 0.50). Isolate of E.coli were 1.83(95%, (11.20-2.79) times likely to be ESBL positive than those of K. pneumonia. Compared to Akwa Ibom, Edo Delta, Rivers and Cross River States were 2.02 (95%, CI 1.05-3.89), 3.20(95%, CI1.69-6.06) and 3.14(95%, CI 1.61-6.14) respectively, were likely to have ESBL positive result. Rivers State was not significant with p-value of 0.47. The study has revealed the presence of ESBL- producing organisms in the study area. It is therefore recommended that concerted efforts must be made to control bacterial resistance to third generation cephalosporin caused by extended spectrum beta lactamases.
Keywords: ESBL-producing organisms, Clinical specimens, South-South geopolitical zone.
Title: PREVALENCE AND ASSESSMENT OF ESBL-PRODUCING ORGANISMS IN THE SOUTH- SOUTH GEOPOLITICAL ZONES OF NIGERIA
Author: ANDY, I.E., TIKU, D.R., OKPO, E.A., UTSALO, S.J.
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
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