Abstract: Plasma prostaglandins (PG) level was measured in 45 patients suffering from eight (8) different types of cancer (leukemia, ovarian, prostate, breast, colon, cervical, uterine, ovarian) attending Ekiti State University Teaching Hospital, Ado Ekiti and Federal Medical Center Ido Ekiti, Nigeria. Forty five (45) healthy subjects served as the control subjects. The Plasma prostaglandins level was estimated by ELISA method as described by Vanweemen and Schuurs (1971). Elevated levels of PGE2 (ng/ml) was recorded in most of the cancer patients with highest level in breast cancer patients when compared with the control subjects and among the various cancer types. Plasma PGE1 (ng/ml) level was found to reduce significantly (p<0.05) in most of the cancer patients with leukemia having the lowest value. However, results obtained from this study may provide clues for future studies of other fractions of prostaglandins in the search for reliable prognostic indicators for cancer.
Keywords: Prostaglandins, cancer, plasma, beast, leukemia.
Title: PROSTAGLANDINS LEVEL IN PLASMA OF CANCER PATIENTS
Author: O.C Ojo
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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