Abstract: Effect of ethanolic extract of Adhatoda vasica against gamma radiation induced changes in terms of body weight and spleen weight in Swiss albino mice was studied at post-irradiation intervals between 1 and 30 days. Mice exposed to 6 Gy gamma radiation showed radiation induced sickness including changes in body weight and spleen weight of mice. When ethanolic leaf extract of Adhatoda vasica was given orally at a dose of 900 mg/kg body weight prior to irradiation showed a significant protection. Mice were divided into four groups i.e. Group I containing normal mice served as control for each experimental groups; group II mice given 900 mg/kg body wt. of Adhatoda vasica extract orally for 15 days; group III mice were exposed to gamma radiation (6Gy) and group IV mice given Adhatoda vasica extract for 15 days then exposed to gamma radiation (6 Gy). There was significantly lesser degree of reduction in body weight and spleen weight to extract treated plus irradiated mice. But there was higher degree of reduction in irradiated mice body weight and spleen weight.
Keywords: Adhatoda vasica, gamma radiation, body weight, spleen and oral administration.
Title: Protective Effect of Adhatoda vasica leaf extract on body weight and spleen weight of gamma-irradiated mice
Author: Mahender Singh
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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