Abstract: Musa paradisiaca often refereed as Banana is an ancient herbaceous flowering plant and the most earlier crop to be cultivated. It is one the important component of diet for all classes of people worldwide. All the parts of the plant is believed to have beneficial effects in different ailments and an excellent nutritional element. The present study was aimed to find the protective effect of Musa paradisiacal fruit extract on acute pancreatitis in rats.
Male Sprague dawley rats were randomly divided in to 4 groups. Control group with normal saline; disease control group where acute pancreatitis was induced by using a single dose of L-arginine (2.5g/kg b.w); Musa paradisiacal fruit extract were prophylactically administered before the induction of acute pancreatitis at a dose of 200 and 400 mg/kg b.w orally in normal saline for 7 days. At the end of the study, blood samples and isolated pancreas were subjected to different pancreatic, antioxidant and inflammatory biomarker analysis. The remaining tissue was subjected to histopathological studies and DNA fragmentation assay for assessing the damage and protection of the tissues.
The results of the study revealed that prophylactic administration of the extracts reduced the amylase and lipase levels when compared to disease control group as well as improved the overall antioxidant status in a dose dependent manner. Further, the extracts also showed a protective effect against apoptosis.
In conclusion, the present study suggest that administration of Musa paradisiacal fruit extract exhibited a protective effect on acute pancreatitis and further investigation is required for its molecular based mechanisms.
Keywords: Musa paradisiacal, acute pancreatitis, free radicals, apoptosis.
Title: Protective Effect of Musa paradisiaca Fruit Extract On L-Arginine Induced Acute Pancreatitis In Rats
Author: Veena Gadicherla, Siva R Challa, Basaveswara Rao M V, Veena Rani I, Geetha Parvathi A
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
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