Abstract: The present study was conducted to evaluate the possible protective effect of soybean and mushrooms on the bone turnover in glucocorticoid-induced osteoporosis female rats. Healthy female divided into six groups: Group I (n=10): Rats were fed on normal diet as negative control. Groups (II to VI)(n=60): Animals was injected with 2 mg dexamethsone sodium phosphate (glucocorticoid) to induce osteoporosis for 3 weeks daily. Group II (n=15): Rats were injected with 2 mg dexamethsone sodium phosphate as positive control. Group III (n=15): Rats were injected estrogen (25 mg/kg.b.w/day). Group IV (n=10): Rats were fed on diet containing 20% mushroom. Group V (n=10): Rats were fed on diet containing 20% soybean. Group VI (n=10): Rats were fed on normal diet containing 10 % soybean and 10 % mushroom. Data obtained revealed that group II exhibited significantly decrease in body and femur bone weight, calcium and phosphorus concentrations in serum and femur bone , serum osteocalcin , alkaline phosphatase, vitamin D and significantly increases in parathyroid hormone when compared with group I. Treatment with mushroom or combined with soybean revealed improvement in body and femur weight, calcium , phosphorus and magnesium concentrations in serum and femur bone , serum osteocalcin , alkaline phosphatase, vitamin D and significantly decrease in parathyroid hormone when compared with group II. Histopathological examination showed cracks-wide Haversian canals-thin trabeculae. This study demonstrates that mushroom alone or combined with soybean possesses positive effect to protect against osteoporosis.
Keywords: Osteoporosis, mushroom, soybean, glucocorticoid, rats.
Title: Protective Effect of Soybean and Mushroom against Glucocorticoid-Induced Osteoporosis in Female Rats,
Author: Bushra S. ALSahafi, Maryam A. Al-Ghamdi , Etimad A. Huwait, Taha A. Kumosani, Reem AL-Wafi ,Turkyah J. Al-Bogami, Moselhy SS
International Journal of Life Sciences Research
ISSN 2348-3148 (online)
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