Abstract: Persistent pulmonary hypertension of the newborn (PPHN) is severe cardiopulmonary condition identified by raised mean pulmonary artery pressure (mPAP) and prolonged direct exposure of the right ventricle to high afterload. but more substantial cause of respiratory distress in babies than others like transient tachypnea of newborn, breathing distress syndrome and etc. An incidence is of 1.9 per 1000 live-births (0.4 - 6.8/ 1000 live births) have been reported, and death rate varying from 4 - 33%have been reported. Current study was aim to focus on pulmonary hypertension and mostly on Persistent pulmonary hypertension of the newborn (PPHN). In addition to evaluate the diagnostic procedures, and treatment intervention, and before all that we intended to discuss the pathophysiology of PPHN. Electronic search was conducted through famous medical databases; PubMed/Midline, and Embase, searching literature on Persistent pulmonary hypertension of the newborn (PPHN), we searched studies that were published in English language only, and up to December,2016 and with only human subjects. Moreover, we searched the references lists of each identified article for more relevant studies. PPHN is a prevalent neonatal issue whose trademark medical function is oxygenation failure, yet it represents a spectrum of physiologic factors that need to be considered when making medical choices. Neonatal intensivists must recognize and follow the basic therapeutic method consisting of the judicious use of oxygen, the administration of Inhaled nitric oxide (iNO) and accomplishment of suitable lung recruitment. It is equally essential not to forget the fundamental physiologic reasoning, which forms the basis of this method and is based on management of elevated PVR. When thinking about alternative pulmonary vasodilators or drugs to support best ventricular performance, the latter is most pertinent.
Keywords: Persistent pulmonary hypertension of the newborn (PPHN), Diagnosis, and Treatment.
Title: Pulmonary Hypertension in the Newborn, Pathophysiology, Diagnosis, and Treatment
Author: Fahad Salem Saad Algarni, Abdullah Faisal Almudaini, Sultan Mousa Alkhrmani, Reiad abdulelah almohamadi, Meshal Ahmed Alqahtani, Waleed Mohammed Alsohaimi
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
