Abstract: Evidence on treatment of Pyoderma gangrenosum (PG) were reviewed aiming to describe the proper management option for PG, also in this review intended to discuss the diagnosis, and pathophysiology of PG, to have great understanding for present concerned dermatological disease. PubMed, Embase databases were searched for relevant articles, related to the Pyoderma gangrenosum (PG), wether concerned with treatment challangest or diagnostic approach or even clinical features of PG, which are published before the end of 2016, and contained only human subjects. No language restriction was applied in this search. Pyoderma gangrenosum is a serious however uncommon ulcerating skin disease, the treatment of which is mainly empirical. Pyoderma can provide to a range of health specialists and a number of versions exist that may not be recognised immediately. The finest recorded treatments are systemic corticosteroids and ciclosporin A. Combinations of steroids with cytotoxic drugs are used in resistant cases. The combination of steroids with sulfa drugs or immunosuppressants has been utilized as steroid-sparing methods. Anti-tumor necrosis alpha treatment in Crohn's disease showed a fast response of PG.
Keywords: Pyoderma gangrenosum (PG), dermatological disease, treatment, human subjects.
Title: Pyoderma Gangrenosum,Treatment Challenges
Author: Mohammed Ahmed M Alabyad, FAWAZ TARIQ H ALSAMDANI, Abdullah Ahmed A Alghamdi, Khalid mohamad gormallh al-ghamdi, Awatef Ayed M Alshammari, FAEZ MOHAMMADHASAN ZAGZOUG
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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