Abstract: Background: Metformin therapy for adults and children with type 2 diabetes mellitus is well established. However, its role in the treatment of insulin resistance and obesity in children and adolescents has not been clearly defined. Objectives: We evaluated the effects of metformin on body composition and insulin sensitivity in children with exogenous obesity. Design and context: Patients referred to a pediatric endocrinology clinic were included in a randomized, double-blind, crossover trial. , patients: 28 patients (13 men) aged 9 to 18 participated in the study. Intervention: Patients received metformin (1 g twice daily) and placebo for 6 months, each with an elimination period of 2 weeks. Results: Mean age of subjects at baseline was 12.5 ± 2.2 years, mean body mass index z-score was 2.54 (range, 1.93–2.85). Metformin was more effective than placebo for weight (–4.35 kg, P = 0.02), body mass index (–1.26 kg/m2, P=0.002), waist circumference (—2.8 cm, P=0.003), abdominal adipose tissue sc (—52.5 cm2, P=0.0.002) and fasting insulin (—2.2 mU/liter, P = 0.011). IS improved in 45% of metformin and 27% of placebo subjects (P = 0.21). Conclusions: Treatment with metformin in insulin-resistant obese pediatric patients significantly improves body composition and fasting insulin. Although improvement in Si has been noted in many individuals, Si is a less useful parameter for group data analysis, possibly due to the effect of variable conformance and Si change in adolescent.
Keywords: Metformin therapy, type 2 diabetes, insulin sensitivity.
Title: Randomized, Controlled Trial of Metformin for Children with Type 2 Diabetes Mellitus
Author: Mesfer Abdulhadi Aldosari, Asma Mohammed Alenezi, Mohammed Eid Baaj Alotaibi, Abdullah Fahad Alroays
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 11, Issue 3, July 2023 - September 2023
Page No: 51-58
Research Publish Journals
Website: www.researchpublish.com
Published Date: 09-August-2023
