Abstract: This double-blind, placebo-controlled clinical study evaluated the effects of iron supplementation on cognitive function in adolescent girls with non-anaemic iron deficiency. Methods Seven hundred and sixteen girls enrolled in four Baltimore high schools were evaluated for nonanemic iron deficiency (serum ferritin <12 µg/L with normal hemoglobin). Ninety-eight (13.7%) girls were non-anemic iron deficient, of whom 81 subjects were randomized to receive oral iron sulfate (650 mg twice daily) or placebo for 8 weeks. The effect of iron treatment was assessed using questionnaires, hematological and cognitive tests administered before the start of treatment and repeated after the procedure. Results Of the 81 non-anemic iron-deficient girls, 78 (96%) completed the study (39 in each group). Five girls (three control, two treatment girls) developed anemia during the intervention and were excluded from the analyses. Ethnic distribution, mean age, serum ferritin concentrations, hemoglobin concentrations and cognitive test results of the groups did not differ significantly at baseline. The hematological measurements of the iron status after the intervention improved significantly in the treatment group (serum ferritin 27.3 vs. Regression analysis showed that girls who received iron performed better than girls in the control group on a test of verbal learning and memory (p<0.02).Interpretation In this urban population of nonanemic iron-deficient adolescent girls, iron supplementation improved verbal learning and memory.
Keywords: iron supplementation, adolescent girls, nonanemic iron deficiency, verbal learning, memory.
Title: Randomized study of cognitive effects of iron supplementation in non-anemic iron-deficient adolescent girls
Author: Ghazi Abdullah Alsubaie, Naif Ali Alqahtani, Zaid Mohammed Alshammari, Salem M AlMutairi
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 11, Issue 1, January 2023 - March 2023
Page No: 6-9
Research Publish Journals
Website: www.researchpublish.com
Published Date: 13-January-2023
